Management of PVCs depends on the presence or absence of symptoms and whether or not the patient has an underlying structural cardiac disease. Persistent PVCs that cause significant related symptoms are initially treated with beta-blockers or non-dihydropyridine calcium channel blockers. If patients have refractory PVC-related symptoms, then catheter ablation and antiarrhythmic therapy are appropriate. 

If a patient is asymptomatic without any structural heart disease, they can be reassured and do not require any further interventions. If a patient is asymptomatic but noted to have a high burden from the PVCs (e.g., a reduced left ventricular ejection fraction), they should be treated with a beta-blocker or non-dihydropyridine calcium channel blocker. Asymptomatic patients with underlying structural heart disease should have appropriate therapy specific to the heart condition.