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Introduction to ECG Interpretation

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Article at a Glance

  • It is important for clinicians working in emergency and critical care to have a basic understanding of electrocardiogram (ECG) interpretation.
  • Impulses traveling toward a positive electrode will have an upward deflection, while impulses traveling away from a positive electrode will have a negative deflection.
  • The ECG grid shows electrical activity of the heart and the time it takes for impulses to travel.
  • Lead II is commonly chosen as the monitoring lead.
  • ECG waves are labelled alphabetically, beginning with the letter P.

Many healthcare providers taking advanced cardiac life support (ACLS) must know how to interpret the 12-lead electrocardiogram (ECG, or EKG in some countries), particularly those who work in emergency and critical care medicine. An electrocardiogram measures electrical signals from the heart.1

Electrodes that detect electrical activity are attached to the skin, and the ECG machine interprets these signals. The output is an ECG tracing that records the time versus amplitude of electrical vector projections and is representative of the heart’s conduction system. 

Standard ECG interpretation makes use of 12 leads, as opposed to rhythm recognition, which only requires a 6-second strip obtained from a few leads.

An electrocardiogram 12-leads placed on his chest.

An electrocardiogram measures the electrical activity of the heart.

Electrical Flow and Vector Projection

In the absence of electrical signals flowing toward the positive or negative ends of the electrodes, the ECG machine will record a flat line, also known as an isoelectric line, where the net voltage is 0 millivolts.2

If an impulse is detected that travels toward the positive terminal of the electrode, the ECG machine will record an upward deflection. If an impulse is detected that travels away from the positive terminal of the electrode, the ECG machine will record a downward deflection.

Electrical flow and vector projection – ECG.

If an impulse travels toward the positive terminal, the electrocardiogram machine will record an upward deflection and vice versa.


Related Video – Chest Pain EKG Interpretation for ACS


The ECG Grid

The ECG grid is divided into 1 × 1 mm small squares and demarcated with heavier lines that form large squares consisting of 5 × 5 small squares. Vertically, the squares represent the deflections of electrical activity (volts), while horizontally, the squares represent the time (in seconds) that has elapsed during the recording of the cardiac signal.

On the ECG’s default settings, 10 vertical small squares represent 1 millivolt.3 If a patient produces large deflections, the ECG settings can be adjusted so that five small squares can represent 1 millivolt. Therefore, it is important to review the ECG settings before interpreting the results.

Each horizontal small square represents 0.04 seconds; therefore, five small squares equal 0.20 seconds.

ECG grid lines.

The gridlines on an ECG grid correlate with time.


Read: Ventricular Rhythms and Asystole


The 12 Leads

Electrode placement on the patient is important because it provides a consistent point of view of the heart’s electrical pattern, similar to “photographing” the heart’s electrical state at different angles, where each view corresponds to a certain lead.

The clinician interprets the pattern in each lead by identifying the waves, complexes, and intervals. Each recorded lead will show a different pattern. This is attributed to the location of each lead where the recorded electrical amplitudes differ from one location to the next.

When analyzing arrhythmias, a single lead is chosen that represents the heart’s overall electrical pattern. This is known as the monitoring lead. The most common monitoring lead is Lead II, where all the deflections are positive (or should be).

12-Lead placement.

Each 12-Lead electrode detects a different vector.

A normal sinus rhythm ECG output.

A normal sinus rhythm ECG output.


Related Video – One Quick Question: How Can I Remember Contiguous 12-Lead ECG?


Waves, Complexes, Segments, and Intervals

The ECG waves are labeled alphabetically beginning with the letter P, followed by QRS, then T (and if significant, there may be a U). When the letters are bundled together, this is known as a complex, hence the QRS complex.4

ECG tracing of a normal sinus rhythm.

The ECG wave is designated by the letters P through T.

The P Wave

The P wave represents right atrial depolarization followed by left atrial depolarization. This is a low- amplitude positive deflection that occurs before the QRS complex. Its amplitude is generally less than 0.25 millivolts, or less than 2.5 small squares, and its duration is less than 120 milliseconds (0.20 seconds), or less than 3 small squares.

The PR Interval

The PR interval is the time recorded from the beginning of the P wave to the PR segment. It represents the time of atrial depolarization and conduction through the atrioventricular (AV) node and the His-Purkinje system. 

This interval is dependent on heart rate and is usually between 120200 milliseconds (0.120.20 seconds), or three to five small boxes. It is shorter in faster heart rates due to the enhancement of AV nodal conduction and is prolonged in bradycardia due to slower AV nodal conduction. 

The QRS Complex

The QRS complex represents ventricular depolarization and normally lasts for 60100 milliseconds (0.06 0.10 seconds), or 1.52.5 small boxes. Its magnitude is not influenced by heart rate. 

The initial deflection, the Q wave, is negative due to septal depolarization. The next positive deflection, the R wave, represents depolarization of the ventricular myocardium. The next negative deflection is the S wave, and it represents the end of the depolarization occurring at the high lateral wall. 

The ST Segment

The ST segment occurs between the end of ventricular depolarization and the beginning of repolarization. It is also known as the time of electrocardiographic silence because it is usually isoelectric with a slight upward concavity in the normal heart. Within this segment is the J point, which is the point that is intersected by the end of the QRS complex and the beginning of the ST segment. 

The T Wave

The T wave represents the period of ventricular repolarization. The T wave has a slow and broad positive deflection pattern that rapidly returns to the isoelectric line because repolarizations occur slowly as compared with depolarizations; therefore, its shape should be asymmetrical. 

The amplitude of the T wave is also variable. The QRS complex and the T wave should have the same direction of deflection; therefore, the QRS complex and the T wave are concordant with each other. If an irregular pattern occurs in the T wave (a notch, a bump, a ripple, or a nipple), then the clinician can consider that the P wave has been superimposed within the T wave. 

The QT Interval

The QT interval is the time recorded that includes the QRS complex, the ST segment, and the T wave. When these time intervals are added up, the QT interval represents ventricular repolarization. The QT interval is dependent on heart rate. It is shorter when the heart rate is faster and vice versa.

The U Wave

The U wave may be seen in precordial leads V2 to V4. It is believed to be the repolarization of the His-Purkinje system and the late repolarization of M cells at the mid-myocardial level due to its longer action potential when compared to the endocardium and epicardium. 

The U wave is pronounced in bradycardia and hypokalemia. Its amplitude is typically less than 200 millivolts. If the QT interval is prolonged, it is often because the U wave has merged with the T wave.


Related Video – Systematic Approach to ECG Interpretation


It is important for clinicians to have a basic understanding of ECG interpretation. This article introduces the ECG grid and the various components of the sinus rhythm.

More Free Resources to Keep You at Your Best

ACLS Certification Association (ACA) uses only high-quality medical resources and peer-reviewed studies to support the facts within our articles. Explore our editorial process to learn how our content reflects clinical accuracy and the latest best practices in medicine. As an ACA Authorized Training Center, all content is reviewed for medical accuracy by the ACA Medical Review Board.


1. Mayo Clinic. Electrocardiogram (ECG or EKG). 2021.

2. Anthony H. Kashou; Hajira Basit; Ahmad Malik. ST Segment. National Library of Medicine. 2021.

3. Ashley EA, Niebauer J. Conquering the ECG. Cardiology Explained. 2004.

4. Steven Douedi; Hani Douedi. P Wave. National Library of Medicine. 2021.

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