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Genetics of Sickle Cell Disease Video
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Video at a Glance
- Sickle cell disease is an inherited genetic disorder transmitted via recessive traits.
- The eleventh chromosome forms the beta chain of hemoglobin, and this is the site of the genetic mutation that causes sickle cell disease.
- Sickle cell disease is recessive, so both the mother and father’s chromosomes must have a copy of the mutation.
- In sickle cell disease, the adenine nucleotide is replaced by a thymine nucleotide, converting the glutamate amino acid into a valine amino acid and creating hemoglobin S.
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