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Oncogenes and Tumor Suppressor Genes Video
ACLS Certification Association videos have been peer-reviewed for medical accuracy by the ACA medical review board.
Video at a Glance
- Tumor suppressor genes suppress genetic mutations that lead to cancer development via cell cycle regulation, DNA repair, and apoptosis.
- Mutations within tumor suppressor genes increase the likelihood of cancerous development.
- For example, tp53 is an essential tumor suppressor gene. In fact, around 50% of all solid tumors have a mutation to the tp53 gene.
- Oncogenes are the opposite of tumor suppressor genes, as they create new proteins that encourage mutation development.
- Oncogenes increase the rate of mitosis, stimulate growth factor secretion, and have positive angiogenetic factors.
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