Get ACLS Certified Today
Hypersensitivity Reactions and Lupus Video
ACLS Certification Association videos have been peer-reviewed for medical accuracy by the ACA medical review board.
Video at a Glance
- There are four types of immune responses and hypersensitivity reactions.
- Type I response involves the immunoglobulin IgE, which attaches to an antigen and creates an antibody-antigen complex that binds with the mast cell and releases a histamine load, resulting in vasodilation, urticaria, hives, larynx swelling, and possible anaphylactic shock.
- Type II responses are tissue-specific and follow a five-step process. Antigens deposit in tissue, antibodies bind to the tissue, complement reactions and inflammation occur, neutrophils undergo phagocytosis, and cell death results.
- Type III hypersensitivity responses are caused by the IgM immunoglobulin. Allergic glomerulonephritis is a type III reaction.
- Type IV reactions are called delayed hypersensitivity reactions and include poison ivy.
- Systemic lupus erythematosus is a hypersensitivity reaction where there’s heightened activity of B cells and T helper cells, elevated immunoglobulin production, decreased activity of suppressor T cells, and apoptosis.
- The manifestations of systemic lupus are rash, arthritis, lung lesions, Raynaud disease, and nephritis.
More Free Resources to Keep You at Your Best
Editorial Note
ACLS Certification Association (ACA) uses only high-quality medical resources and peer-reviewed studies to support the facts within our articles. Explore our editorial process to learn how our content reflects clinical accuracy and the latest best practices in medicine. As an ACA Authorized Training Center, all content is reviewed for medical accuracy by the ACA Medical Review Board.