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Anaphylaxis: Pathophysiology Video
ACLS Certification Association videos have been peer-reviewed for medical accuracy by the ACA medical review board.
Video at a Glance
- This video discusses the pathophysiology of anaphylaxis.
- Anaphylaxis is a classic type 1 immune response that occurs when an antigen is introduced to the body that binds with Immunoglobulin E (IgE). IgE then binds with a mast cell which initiates histamine release.
- Histamine release causes vasodilation and capillary leak which leads to edema throughout body systems as well as decreased intravascular volume.
- The ABCs of anaphylaxis are Airway swelling and obstruction, Breathing obstruction, and Circulation obstruction leading to distributive shock.
- The skin will present with anaphylactic effects, including hives and angioedema.
- Cytokine release during anaphylaxis and the subsequent stress response may cause plaque rupture.
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ACLS Certification Association (ACA) uses only high-quality medical resources and peer-reviewed studies to support the facts within our articles. Explore our editorial process to learn how our content reflects clinical accuracy and the latest best practices in medicine. As an ACA Authorized Training Center, all content is reviewed for medical accuracy by the ACA Medical Review Board.